Thursday, 28 July 2011

George's 18th Birthday

Today should have been George's 18th birthday. Instead it's just a little over three months since his death, on April 25th 2011. We miss him always but today it hurts so much more because we know how much it would have meant to him. He should have had a whole life to look forward to...

Although we are consoled by the knowledge that he knew how much we loved him, and that he loved us in return, the injustice of it all is still hard to deal with.The world moves on, but for us, the world is a poorer place without him.

Monday, 25 July 2011

Meeting your oncologist

Most of the articles on this site have so far focused on cancer research or the politics of that research. However, the intention is to do more than just summarise results or to argue for changes in policies, it is also firmly about providing practical support and advice to cancer patients, their families and friends. With that in mind this post is going to look at something that might seem trivial but in reality is absolutely essential – how to approach the meetings with your oncologist or other specialist. While some people will view an article like this as being a bit pointless, there are others who might gain some useful tips, particularly as we all have a tendency to defer to our doctors. The whole area of doctor-patient relationship is a bit of a nightmare, for all sides, but unless that relationship is solid things will be more difficult than they should be.

When you first get your diagnosis, or when waiting for results from scans or examinations, you will be stressed on meeting your doctors. No matter how much you like them or respect them, you’ll be feeling tense and nervous, a not a little apprehensive. Sitting in the waiting room can be hard, especially if the clinic is running late and you’ve been waiting for ages (which was the norm, in our experience). At times like these it’s easy to get so stressed that you forget to ask the things you’ve been meaning to ask. It’s ridiculous, because you may have been waiting for ages to ask these questions, but you can be blindsided by news (good or bad), get diverted by some other train of thought or simply forget everything and just sit there passively while the doctor leads the discussion. Afterwards, you’ll kick yourself for not having remembered to ask your questions and will either have to wait for the next appointment or get on the phone or look for someone else to ask.

Thursday, 21 July 2011

Curcumin and the Drugs Industry

Looking through some of the previous articles on this site you’ll notice frequent mentions of curcumin. Of the many food-based anti-cancer agents, this extract from turmeric (the yellow spice used in curry), is one that generates a lot of scientific interest. Curcumin has anti-oxidant, anti-inflammatory and a wide range of anti-cancer properties. It is cheap, non-toxic and has been used as a traditional medicine for hundreds of years. In terms of research, it has plenty of in vitro and in vivo evidence against a wide range of different cancers. What’s more, there have been early stage clinical trials that show that even at high doses curcumin is non-toxic. There are lots of positives about curcumin, but there are also some significant issues. First and most obvious is that it suffers from very low levels of bioavailability. In other words it takes a lot of curcumin to generate even low levels in the blood stream. Secondly, most of the in vitro and in vivo studies use the raw material, but when we take it orally it gets metabolised as we digest it, so it’s not pure curcumin that circulates in the body (though in the digestive tract things are different, obviously). These issues are not unique to curcumin by a long shot, and they are discussed in more detail in the articles on How To Read A Cancer Paper (here and here).

Even with those caveats, curcumin is an interesting substance that bears closer investigation. But, given the urgency with which we want the research to proceed, you have to ask yourself why such a positive drug candidate has not moved further. Where are the large scale trials in cancer patients? Why isn’t curcumin part of the everyday armoury that we use against cancer?

Thursday, 14 July 2011

Q&A with Dr Gerald Krystal - Low carbs and cancer

Following my recent article on a recent paper that looked at the effect that a low carb diet had on slowing tumour growth (and if you haven’t read it, I suggest you do that before reading the rest of this…), I contacted one of the authors, Dr Gerald Krystal of the University of British Columbia with a list of questions. Dr Krystal has kindly responded with some more information, which I think is useful for those people considering starting a low carb diet in line with the results of his team’s work.

PP: The low carb diet includes foods high in amylose. Doesn't this make it difficult to translate into a diet people can follow? Are there foods that are naturally high in amylose?

GK: There are many foods that are naturally high in amylose. For example, all legumes (beans, lentils and peas), basmati rice, new potatoes, bananas, whole grains, sweet potatoes, radishes and parsnips. Try and avoid regular "old" potatoes, white rice and white bread (whole wheat bread is not much better….bread with whole grains is the best when it comes to breads but I try and avoid all breads. If you can't resist, sourdough is not bad because of its low pH…if you add a tsp of lemon juice or vinegar to any meal you can lower the glycemic index by about 1/3). Another interesting tip is if you let cooked rice cool it becomes more resistant to digestion so eating sushi is better than eating hot cooked white rice. I would love to see a breakdown of digestible carbs into % amylose and % amylopectin down the road on food products. Also, there are ongoing studies in the US to generate genetically modified potatoes (lacking 2 enzymes that are used to put the branched sugars on the glucose polymer to convert it from a linear glucose polymer (amylose) to a branched glucose polymer (amylopectin, which is more easily broken down). Don't know how you feel about genetically modified foods but this could dramatically lower blood glucose spikes after eating potatoes.

PP: Why is it that so much mainstream dietary advice for cancer patients seems so unhealthy? Why are patients still being encouraged to have high calorie diets?

GK: This drives me crazy as well. The main concern of cancer clinicians today is cachexia (wasting). I understand this is something you want to avoid but I think that lowering our carb and raising our protein intake will have a substantial benefit, especially for early pre-metastatic cancers. In keeping with this I would like to see clinicians substitute amino acid/PBS intravenous drips for the currently used 5% dextrose (glucose) PBS to rehydrate cancer patients.

Tuesday, 12 July 2011

Low carb diets and cancer

The Warburg Effect
It is well known that a hall-mark of cancer cells is an increase in the use of glucose – the so-called glycolytic switch is an early indicator of malignancy (a change that is a part of the Warburg effect – which is worth following up if you're interested). This greediness for glucose is exploited in PET scanning, where radioactively tagged glucose is injected into the patient and, several hours later, a scan is taken to track where the radioactivity has accumulated in the body. Tumours absorb much higher amounts of this radioactive glucose than the normal tissues, and show up as 'hot spot' on the scans.

Tackling this greediness for glucose underlies a number of different approaches to attacking cancer, and one obvious avenue for this is to look at diet. Before we get into this, however, it's worth pointing out that many mainstream oncologists and dieticians are incredibly blasé about this topic. From our experiences in many different hospitals and with different doctors, we know that the mainstream advice for cancer patients is not to change the diet in any major way. Time and again we were told that keeping the calorie intake high and maintaining weight were the most important considerations. Any questions about limiting carbohydrate intake to starve tumours were simply dismissed as untested and unproven hypotheses and therefore best avoided.

That said, there have been numerous studies that have looked at the influence of diet on cancer growth. Many of these have been rodent studies, but there have also been some patient studies performed, mostly these have looked at brain tumours (glioblastoma). Furthermore, much of this research has involved a ketogenic diet, which is a high-fat and extremely low-carb diet, which has been used clinically in the treatment of epilepsy. In terms of being able to follow this yourself, it's no easy task, this is an extreme diet, much more extreme than the strictest Atkins diet for example.

Sunday, 3 July 2011

How To Read A Cancer Paper - Part 2

By Pan Pantziarka

In the first article in this series we looked at interpreting the results of in vitro studies, particularly those that look at the effect of different substances on tumour cells. In this second piece we focus attention on in vivo studies – in other words studies that take place in living tissue rather than in a Petri dish. For the most part these studies use rats and mice, though sometimes you'll find other animals being used. Again we will focus cancer research of the sort that looks at what effect a given substance (particular foods, supplements, vitamins or minerals, drugs etc) has on cancer.

Mice and Rats
The good news is that if you are a rat or a mouse there has never been a better time to have cancer. Again and again we see fantastic results in rodents. Cancers of many different sorts are slowed, stopped, destroyed. It is impossible not to feel excited by some of these results, and they are truly remarkable. Unfortunately however, these fantastic results on lab rats do not translate as well to humans. Why is that? We saw that test tube studies have all kinds of issues, surely these problems disappear once you move from glass dishes to living beings?

Some of the disadvantages of the test tube approach are easily solved in rats, mice and other animals. No longer do you have just a flat layer of cancer cells to bathe in your anti-cancer agent, instead you have three-dimensional tumours embedded in tissue, with a blood supply and tumour microenvironment. And, interestingly enough, we find that some agents that have fantastic results in the test tube are all of a sudden not so powerful against tumours. Instead the same agents have lower efficacy and in some cases seem to have lost all trace of anti-cancer effect. Why? Because the high dosing and guaranteed test tube conditions cannot be transferred to a living being. Doses that killed tumour cells under glass can also be toxic to living animals. In some cases you find that there is what is termed a biphasic response – at the lower dose that can be achieved in animals the agent turns out to be pro-cancerous, and at the higher dose it does kill the tumours but also kills the animals or makes them seriously sick. Not good.

Windfarms or cancer treatment?

Writing in the Daily Telegraph, Energy Secretary Chris Huhne states that:

A low-carbon economy presents an opportunity, not a cost. Investment in our clean energy future should not be mistaken for a cost to the economy, or the public purse…Globally, the low-carbon goods and services industry is worth £3.2 trillion, and employs 28 million people.

In a withering response, Tim Worstall, takes Huhne’s arguments apart and shows, yet again, the idiocy of current climate and energy policy. In passing Worstall makes the comment that:

…an economist would point out those are costs. 28 million people not curing cancer but faffing about with windmills. This is a cost of getting windmills, for we get windmills not the cure for cancer.

Some would argue that a blog about cancer and cancer-research is not the place to be discussing either climate change, energy policy or economics. I strongly disagree. At every stage, from screening, to diagnosis to treatment, economic decisions are at play. And those decisions can be the difference between life and death. We live in a world where there are not endless resources, there is no bottomless pit of money, therefore decisions about where money is spent have to be made, no matter how distasteful or hard those decisions are.

We are not having a grown up discussion of these issues in this country. We are not presented with choices that say spend money on windmills or on health care, on subsidising solar versus paying for new treatments. Yet these decisions are being made all the time. Instead we are told to focus on the distant future when climate change might or might not be a problem. We are told that we have to save the planet, that our grandchildren’s children will thank us, that we owe it to planet Earth.